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Information

ANTIBIOTICS

FLUOROQUINOLONES

Some commonly used brand names include: Cipro, Floxin, Maxaquin, Noroxin, Penetrex.

Ciprofloxacin, (Ciloxan, Ciproxin), Enoxacin, Lomefloxacin, Norfloxacin, (Utinor), Ofloxacin (Tarivid)

In the American Drug Information manual USPDI under Advice for Patients it is stated:

Before Using This Medication - " In deciding to use a medicine, the risks of taking the medicine must be weighed against the good it will do. This is a decision you and your doctor will make.

For the fluoroquinolones, the following should be considered:

ALLERGIES - Tell your doctor if you have ever had any unusual or allergic reaction to any of the fluoroquinolones or to any related medicines such as cinoxacin (e.g. Cinobac) or nalidixic acid (e.g. NegGram).

Also tell your health care professional if you are allergic to any other substances, such as foods, preservatives, or dyes."

The ASPDI warns about interactions with various medications antacids and iron supplements.

"Caffeine - Enoxacin, ciprofloxacin, and norfloxacin may increase the chance of side effects of caffeine."

Warning from 'APRIL' drinks like Red Bull are high in caffeine content.

These are some of the psychiatric symptoms, edited for the APRIL web site by the incredible lady who runs a web site for sufferers of side effects to Fluoroquinolones.

Please go to her web site for more information. www.geocities.com/quinolones/

Levaquin:

Source: this listing of reactions was retreived from the site below:
http://www.rxlist.com/cgi/generic/levoflox_wcp.htm

Convulsions and toxic psychoses have been reported in patients receiving quinolonas, including levofloxacin.

Quinolones may also cause increased intracranial pressure and central nervous system stimulation that may lead to tremors, restlessness, anxiety, lightheadedness, confusion, hallucinations, paranoia, depression, nightmares, insomnia, and rarely suicidal thoughts or acts.

These reactions may occur following the first dose.

 If these reactions occur in patients receiving levofloxacin, the drug should be discontinued and appropriate measures instituted.

As with other quinolones, levofloxacin should be used with caution in patients with a known or suspected CNS disorder that may predispose to seizures or lower the seizure threshold (e.g., severe cerebral arteriosclerosis, epilepsy)or in the presence of other risk factors that my predispose to seizures or lower the seizure threshold (e.g., certain drug therapy, renal dysfunction.)

ADVERSE REACTIONS In clinical trials:

The following events were considered likely to be drug-related in patients receiving multiple doses of levofloxacin: insomnia 0.3%, malaise 0.1%, nervousness 0.1%, sleep disorders 0.1%, tremor 0.1%.

In clinical trials, the following events occurred in 1 to 3% of patients, regardless of drug relationship: insomnia 2.9%, dizziness 2.5%.

The following adverse events occurred in clinical trials at a rate of 0.5 to less than 1%, regardless of drug relationship: agitation, anxiety, fatigue, nervousness, somnolence.

 ...Additional adverse events occurring in clinical trials:

Abnormal coordination, abnormal dreaming, aggressive reaction, anaemia, confusion, convulsions (seizures), emotionally lability, hallucination, impaired concentration, manic reaction, mental deficiency, sleep disorders, speech disorder, stupor...

Tequin

Source: http://www.rxlist.com/cgi/generic3/gatifloxacin_ad.htm

Side effects: Nervous System: abnormal dream, insomnia, paresthesia, tremor, vasodilatation, vertigo.

Additional drug-related adverse events considered clinically relevant that
occurred in <0.1% (rare adverse events) of patients receiving gatifloxacin in
single-and multiple-dose clinical trials are as follows:

Abnormal thinking, agitation, anxiety, arthalgia, confusion, convulsion, depersonalization, depression, euphoria, hallucination, hostility, nervousness, panic attack, paranoia, psychosis, taste loss.

Convulsions, increased intracranial pressure, and psychosis have been
reported in patients receiving quinolones.

Quinolones may also cause central nervous system (CNS) stimulation, which may lead to tremors, restlessness, lightheadedness, confusion, hallucinations, paranoia, depression, nightmares, and insomnia.

These reactions may occur following the first dose.

Avelox

Source of information: http://www.rxlist.com/cgi/generic3/avelox_ad.htm

Central Nervous System: insomnia, nervousness, anxiety, confusion, hallucinations, depersonalization, hypertonia, incoordination, somnolence, tremor, vertigo, paresthesia.

Nonsteroidal anti-inflammatory drugs (NSAIDs): Although not observed with
moxifloxacin in preclinical and clinical trials, the concomitant administration of a nonsteroidal anti-inflammatory drug with a quinolone may increase the risks of CNS stimulation and convulsions.

Convulsions have been reported in patients receiving quinolones.

Quinolones may also cause central nervous system (CNS) events including: dizziness,
confusion, tremors, hallucinations, depression, and, rarely, suicidal thoughts or acts.

These reactions may occur following the first dose. If these reactions occur in patients receiving moxifloxacin, the drug should be discontinued and appropriate measures instituted.

General Quinolones may cause central nervous system (CNS) events, including:
nervousness, agitation, insomnia, anxiety, nightmares or paranoia.

Cipro

Source: http://www.rxlist.com/cgi/generic/cipro_ad.htm

Central Nervous System: Dizziness, lightheadedness, insomnia, nightmares,
hallucinations, manic reaction, irritability, tremor, ataxia, convulsiveseizures, lethargy, drowsiness, weakness, malaise, anorexia, phobia, depersonalization, depression, paresthesia.

Less than 1 percent:

Central Nervous System: Convulsive seizures, paranoia, toxic psychosis, depression, dysphasia, phobia, depersonalization, manic reaction, unresponsiveness, ataxia, confusion, hallucinations, dizziness, lightheadedness, paresthesia, anxiety, tremor, insomnia, nightmares, weakness, drowsiness, irritability, malaise, lethargy.

Convulsions, increased intracranial pressure, and toxic psychosis have been reported in patients receiving quinolones, including ciprofloxacin.

Ciprofloxacin may also cause central nervous system (CNS) events including: dizziness, confusion, tremors, hallucinations, depression, and, rarely, suicidal thoughts or acts.

These reactions may occur following the first dose.

If those reactions occur in patients receiving ciprofloxacin, the drug
should be discontinued and appropriate measures instituted.

As with all quinolones, ciprofloxacin should be used with caution in patients with known or suspected CNS disorders that may predispose to seizures or lower the seizure threshold (e.g., severe cerebral arteriosclerosis, epilepsy), or in the presence of other risk factors that may predispose to seizures or lower the seizure threshold.

 


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