APRIL charity   


APRIL is a charity seeking to create awareness that many every day medicines and anaesthetics can induce psychiatric adverse reactions (ADRs) or withdrawal effects including depression, anxiety, insomnia, agitation, self harm, suicidal thoughts and actions, or violence towards others. The content and comments on the web site is largely compiled by founder of APRIL, Millie Kieve with occasional input from volunteer researchers.

URGENT NOTICES - and for latest news you can read our blog:


Benzodizepine & z drug withdrawal information now on official medical site:


 re Ban in France of Dianette / Diane-35

The latest news from MHRA is the EMA have designated Diane 35 / Dianette and generics with a BLACK TRIANGLE - A WARNING that Dianette is under close monitoring for adverse side effects. The black triangle system has been in existence for many years but only now has the Eu Medicines Agency insisted the BLACK TRIANGLE has to be placed on the information in the box of pills. However some pharmacies may not have the new boxes with the black triangle on the drug information and some pharmacists may not be aware. We would like to hear from you about your local pharmacy having patient information with the black triangles and especially would like to know if your GP is aware:     

For more information and a list of medicines now designated BLACK TRIANGLE drugs including Dianette (Cyproterone Acetate & Ethinylestradiol) plus many generic names - and Champix (Verenycline) - access the MHRA web site and put Black Triangle into the search box: http://mhra.gov.uk

The Eu Medicines Agency review for which we were one of 8 stakeholders who responded, The EMA have issued a statement: Some countries were not so keen to re-introduce Dianette and Holland are not recommending the drug for new patients. Search on EMA web site for Diane 35.


We are still interested to receive reports of blood clots, hair loss, depression or any other adverse reaction to Dianette. In the Eu Dianette is called Diane 35 (cyproterone acetate & ethinylestradiol).

Sadly some doctors fail to link depression with medication, including Dianette, they may have prescribed and are too hasty in picking up a pen to write a prescription for antidepressants. What a pity the GPs fail to read latest informaton or even discuss with their patient the possibility of a 'drug holiday'. By stopping a drug, or reducing a dose, many tragedies could be avoided.

Be aware: Some medicines should not be stopped suddenly.

A recent suicide of young person taking Dianette and prescribed antidepressants may have been avoided if the doctor had been more aware.

Information about Dianette links to depression - just click highlighted words.

Some stats for you to contemplate:

  • 1/16 in admission to hospital were found to be as a result of adverse drug reactions, excluding psychiatric ADRs ( BMJ 2004 Jul 3;329(7456):15-9.Pirmohammed study).

  • Hospital admissions due to adverse drug reactions (ADRs) in England increased by 76.8% over 10 years. ADRs as cause of emergency admission rose faster than any other cause ( J R Soc Med 2010 June 1; 103(6): 239–250)

APRIL colates information from academics, doctors and patients about neuro-psychiatric adverse drug reactions (ADRs).

We campaign for truthful information about all known possible adverse side effects, on patient leaflets and transparency of all clinical trials data.

Medical students can currently qualify without proven competence to prescribe or recognise ADRS. APRIL campaigns for inclusion of pharmacology in exams and medical courses.

We  use evidence from patients who have suffered psychiatric ADRs apparently caused by prescribed medicine, or following anaesthetic and drugs used during or following surgery, in our campaigns.

We hold meetings and conferences and give talks to medical professionals to create awareness of patient experiences and the extent of suffering in the community due to ADRs.

If you are feeling depressed? then please click highlighted link.


When taking any prescribed medication, always read the Patient Information Leaflet that should be provided. Keep for reference.

If you are worried that medication is having an adverse effect in any way, immediately seek professional medical help, or speak to a pharmacist.

Be aware: Some medicines should not be stopped suddenly.

Audio information about APRIL. listen to Millie Kieve, the founder, in the following BBC Essex radio broadcast (with psychologist Martin Seager and presenter Dave Monk):

Radio interview - Depression - Role of the psychologist - medicines effects - pharmaceuticals marketing and more from APRIL on Vimeo.

 For more audi and video about Adverse psychiatric reactions (ADRs) to medicines and anaesthetics - and personal stories of bereaved parents and victims of ADRs go direct to VIMEO web site: http://vimeo.com/user1816628/videos

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