SSRIs Antidepressants (Selective Serotonin Re-uptake Inhibitors)
(also see the antidepressants section)
If you are taking antidepressants, make sure you have regular blood tests to check your potasium levels and kidney and liver function.
Selective serotonin reuptake inhibitors (SSRIs) are a class of antidepressants used in the treatment of depression, anxiety disorders, and some personality disorders. The first class of psychotropic drugs to be rationally designed, SSRIs are the most widely prescribed antidepressants in many countries. Their effectiveness and safety have been questioned.
List od SSRIs
Citalopram (Celexa, Cipramil, Emocal, Sepram, Seropram)
escitalopram (Lexapro, Cipralex, Esertia)
fluoxetine (Prozac, Fontex, Seromex, Seronil, Sarafem, Fluctin, Fluox)
fluvoxamine (Luvox, Faverin, Dumyrox)
paroxetine (Paxil, Seroxat, Aropax, Deroxat, Rexetin, Xetanor, Paroxat)
sertraline (Zoloft, Lustral, Serlain)
zimelidine (Zelmid, Normud)
Psychiatric Adverse Side Effects (ADRs)
General side effects are mostly present during the first 1-4 weeks while the body adapts to the drug (with the exception of sexual side effects, which tend to occur later in treatment).
Almost all SSRIs are known to cause one or more of these symptoms:
Nausea, headache, extremely vivid and strange dreams, dizziness, changes in appetite, changes in sexual behaviour, increased feelings of depression and anxiety (which may sometimes provoke panic attacks), akathisia, suicidal ideation
However, despite being called general, the side effects and their durations are highly individual and drug-specific. Mania or hypomania is a possible side-effect. Users with some type of bipolar disorder are at a much higher risk, however SSRI-induced mania in patients previously diagnosed with unipolar depression can trigger a bipolar diagnosis.
Suicide and Aggression
Similarly to other antidepressants, it is commonly accepted that SSRIs can cause suicidality in children. We all know of adults affected in the same way. Analyses of the risks of SSRIs by governing bodies in the United States and United Kingdom have produced warnings about suicidality and aggression when the medications are used with children and adolescents.
A 2004 Food and Drug Administration (FDA) analysis of clinical trials on children with major depressive disorder found statistically significant increases of the risks of "possible suicidal ideation and suicidal behavior" by about 80%, and of agitation and hostility by about 130%. An additional analysis by the FDA also indicated 1.5-fold increase of suicidality in the 18–24 age group. This resulted in a black box warning on SSRI and other antidepressant medications regarding the increased risk of suicidality in patients younger than 24.
(for more info see
In 2004, the Medicines and Healthcare products Regulatory Agency (MHRA) in the United Kingdom judged fluoxetine (Prozac) to be the only antidepressant that offered a favorable risk-benefit ratio in children with depression, though it was also associated with an increase in the risk of self-harm and suicidal ideation. Only two SSRIs are licensed for use with children in the UK, sertraline (Zoloft) and fluvoxamine (Luvox), and only for the treatment of obsessive-compulsive disorder. Fluoxetine, despite having a favorable risk-benefit ratio for use with depression in adolescents and children, is not licensed for this use.
(for more info see: http://www.mhra.gov.uk/Safetyinformation/Safetywarningsal ertsandrecalls /Safetywarningsandmessagesformedicines/CON019494
IT IS DANGEROUS TO DISCONTINUE ANTIDEPRESSANTS SUDDENLY
Obtain the liquid form of the drug to titrate very slowly.
Always obtain medical advice and support if you are considering reduction of the dose! SSRI drugs such as Seroxat / Paxil and Prozac have been causing problems for some time resulting in law suits which have been settled out of court.
The habit forming nature of SSRI drugs has not been disclosed in an open truthful manner. There are many people, unable to withdraw without severe mental and physical distress. This often results in the patient being told that they are having a relapse when in fact they are suffering serious withdrawal symptoms.
For more information on withdrawing please see left menu 'WITHDRAWAL from medicines'
Related Articles and Links
Provided by US Law Firm Baum Hedlund including testimonies to the FDA from families about the effect of these drugs on their children. These testimonies influenced the FDA to issue warnings about the risk of suicide.
If you have suffered a psychiatric adverse reaction to SSRIs please report see left menu 'REPORTING'.
See also CASE REPORTS
SSRI stories in the press
If you have or know of a case reported in the press concerning SSRI, SNRI and similar antidepressants please submit this to: http://www.ssristories.com/
AWARENESS SAVES LIVES
Please submit a Yellow Card report to the regulator (MHRA)
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